Vitamin A and tumor immunity |
| |
Authors: | Y. Tomita K. Himeno K. Nomoto H. Endo T. Hirohata |
| |
Affiliation: | (1) Department of Public Health, Kurume University School of Medicine, 830 Kurume, Japan;(2) Department of Immunology and Department of Biochemistry, Institute of Bioregulation, Kyushu University, 812 Fukuoka, Japan |
| |
Abstract: | Summary Intraperitoneal administration of vitamin A into the BALB/c mice inoculated with a syngeneic fibrosarcoma, Meth A, caused a remarkable augmentation of tumor rejection. A cell-depletion technique revealed that the primary effector cells responsible for the augmented rejection were Thy-1 positive, Lyt-1 negative, Lyt-2 positive lymphocytes, suggesting the involvement of cytotoxic lymphocytes.This work was supported in part by a Grant-in-Aid for scientific research from the Ministry of Education, Science and Culture, Japan, and in part by a Grant-in-Aid for cancer research from the Fukuoka Cancer Society, Japan.We thank Mr M. Fujiki and Miss A. Maeda for excellent technical assistance. |
| |
Keywords: | Mouse, BALB/c fibrosarcoma Meth A vitamin A, tumor rejection lymphocytes, cytotoxic |
本文献已被 SpringerLink 等数据库收录! |
|