Vitamin A and tumor immunity |
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| Authors: | Y Tomita K Himeno K Nomoto H Endo T Hirohata |
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| Institution: | (1) Department of Public Health, Kurume University School of Medicine, 830 Kurume, Japan;(2) Department of Immunology and Department of Biochemistry, Institute of Bioregulation, Kyushu University, 812 Fukuoka, Japan |
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| Abstract: | Summary Intraperitoneal administration of vitamin A into the BALB/c mice inoculated with a syngeneic fibrosarcoma, Meth A, caused a remarkable augmentation of tumor rejection. A cell-depletion technique revealed that the primary effector cells responsible for the augmented rejection were Thy-1 positive, Lyt-1 negative, Lyt-2 positive lymphocytes, suggesting the involvement of cytotoxic lymphocytes.This work was supported in part by a Grant-in-Aid for scientific research from the Ministry of Education, Science and Culture, Japan, and in part by a Grant-in-Aid for cancer research from the Fukuoka Cancer Society, Japan.We thank Mr M. Fujiki and Miss A. Maeda for excellent technical assistance. |
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| Keywords: | Mouse BALB/c fibrosarcoma Meth A vitamin A tumor rejection lymphocytes cytotoxic |
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