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| 复方沙棘对大鼠及小鼠缺血性脑梗塞的防治作用 | |
| 引用本文： | 高丽萍,程体娟,王玉斌,孙以方,张坚.复方沙棘对大鼠及小鼠缺血性脑梗塞的防治作用[J].兰州大学学报(自然科学版),2003,39(3):53-56. |
| 作者姓名： | 高丽萍 程体娟 王玉斌 孙以方 张坚 |
| 作者单位： | 1. 兰州医学院,生化教研室 2. 兰州医学院,药理教研室,甘肃,兰州,730000 3. 甘肃省人民医院,放射科,甘肃,兰州,730000 4. 兰州医学院,实验动物学教研室,甘肃,兰州,730000 |
| 基金项目： | 甘肃省自然科学基金资助项目 ( ZR-97-1 0 1 ) |
| 摘 要： | 小鼠尾静脉注射胶原蛋白与肾上腺素的混合诱导剂诱导体内血栓形成，观察复方沙棘对小鼠体内血栓的影响;采用大脑中动脉阻断术(MCAO)制作大鼠缺血性脑梗塞模型，观察复方沙棘对大鼠行为障碍和脑梗塞范围的影响．结果表明复方沙棘(22．8，45．6g／kg)对胶原蛋白—肾上腺素诱导的小鼠体内血栓有显著的抑制作用．复方沙棘(9．98，19．95g／kg)能明显改善大脑中动脉阻断大鼠的行为障碍，可减少大脑中动脉阻断所致的脑梗塞范围．提示复方沙棘对大鼠脑缺血、脑梗塞具有明显的保护作用． |
| 关 键 词： | 复方沙棘 大脑中动脉阻断术 脑梗塞 磁共振成像 |
| 文章编号： | 0455-2059(2003)03-0053-04 |
| 修稿时间： | 2002年4月8日 |
The preventive function of compound Hippophae rhamnoides L. against ischemic cerebral infarction in rats and mice |
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| GAO Li-ping,CHENG Ti-juan,WANG Yu-bin,SUN Yi-fang,ZHANG Jian.The preventive function of compound Hippophae rhamnoides L. against ischemic cerebral infarction in rats and mice[J].Journal of Lanzhou University(Natural Science),2003,39(3):53-56. | |
| Authors: | GAO Li-ping CHENG Ti-juan WANG Yu-bin SUN Yi-fang ZHANG Jian |
| Institution: | GAO Li-ping1,CHENG Ti-juan2,WANG Yu-bin3,SUN Yi-fang4,ZHANG Jian2 |
| Abstract: | To investigate into the preventive function of compounds Hippophae rhamnoides L. on ischemic cerebral infarction,Thrombosis formation induced by collagen-adrenaline iv was studied in mice.A focal cerebral ischemia model was made by middle cerebral artery occlusion (MCAO) in rats.Behavioral obstacles of rats was observed.Cerebral infarction volume was determined quantitatively by magnetic resonance imaging (MRI).CHRL(ig22.8,45.6 g/kg) markedly reduced thrombosis formation induced by collagen-adrenaline in mice.CHRL (ig9.98,19.95 g/kg) could reduce infarction volume after occlusion of middle cerebral artery in rats and could also ameliorate the behavioral obstacles of rats.The results suggest that CHRL has distinctive preventive function against ischemic cerebral infarction. |
| Keywords: | compound Hippophae rhamnoides L middle cerebral artery occlusion cerebral infarction magnetic resonance imaging |
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