Functional consequences of treating turkey liver fructose-1,6-bisphosphatase with penicillin G |
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Authors: | P F Han S H Pollock H W Matthews J Johnson Jr |
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Institution: | (1) Department of Chemistry, Atlanta University, 30314 Atlanta, Georgia, USA;(2) Southern School of Pharmacy, Mercer University, 30312 Atlanta, Georgia, USA |
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Abstract: | Summary Treatment of turkey liver fructose-1,6-bisphosphatase with penicillin G progressively inactivated the enzyme and desensitized the enzyme toward high substrate inhibition. The treatment also led to reduced sensitivity to AMP inhibition and the loss of cooperative interaction among AMP-binding sites. These altered properties were not reversed by dialysis, but were prevented when treatment with penicillin G was performed in the presence of substrate.This work was in part supported by grant RR-8006 from the General Research Branch, Division of Research Resources, NIH (USA) and in part by Faculty Research Grant from Southern School of Pharmacy, Mercer University, Atlanta (Georgia, USA). |
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