Distribution of polychlorinated biphenyls: Structural requirements for accumulation in the mouse bronchial mucosa |
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| Authors: | I Brandt A Bergman C A Wachtmeister |
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| Institution: | (1) Department of Toxicology, University of Uppsala, Biomedical Center, S-751 23 Uppsala, (Sweden);(2) Present address: Section of Organic Chemistry, Environmental Toxicology Unit, Wallenberg Laboratory, University of Stockholm, S-104 05 Stockholm 50, (Sweden) |
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| Abstract: | Summary Autoradiography showed that labelled polychlorinated biphenyls with chlorine in positions 2, 41, 5 and hydrogen in positions 3, 31, 6, 61 in the molecule are accumulated in the mouse bronchial mucosa. Further testing of this observation showed that 2, 21, 4, 51-tetrachlorbiphenyl-14C, but not biphenyl-14C, was taken up in the bronchi of mice.This investigation was supported by the National Swedish Environment Protection Board. |
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