Covalent and noncovalent modifiers of the p53 protein |
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Authors: | L Jayaraman C Prives |
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Institution: | (1) Department of Biological Sciences, Columbia University, New York (New York 10027, USA), Fax +1 212 865 8246, e-mail: clp3@columbia.edu, US |
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Abstract: | Despite the massive attention it has received, there is still much to learn about the p53 tumour suppressor protein. Given
that it plays complex and multiple roles in cells, it is not surprising that p53 is subjected to an intricate array of regulatory
processes. p53 receives signals from cells in multiple ways, leading to its stabilization and activation. The functions of
the protein are altered by phosphorylation and other covalent modifications. However, a number of proteins can regulate p53
function dramatically by noncovalent means. p53 is thus subjected to numerous signalling and regulatory pathways which we
have only begun to decipher. |
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Keywords: | , Phosphorylation, DNA bending, redox, stabilization, signalling, C-terminus, N-terminus, modification, DNA binding, |
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