不同剂量维生素C对冠心病患者血脂的影响

本研究比较不同剂量维生素C对39名冠心病并有高脂血症患者血脂水平的影响。实验组每天口服Vc剂量如下:A组患者1.2g;B组0.6g,C组0.3g;D组对照,不补充Vc。实验前及投药后的第15天及45天,采血测定血脂等指标。结果为:A、B两组口服Vc第15天轻度抑制,第45天明显降低血清总胆固醇、甘油三酯及低密度脂蛋白水平;与此同时,高密度脂蛋白水平明显升高。不同剂量的各组间比较,以A组(每天1.2克)减轻高脂血症的作用最为明显,C组(0.3g)不明显。血清总抗坏血酸的测定表明,所有冠心病患者的血清VC含量明显低于正常水平,补充Vc后很快上升。

Effect of Different Dosage of Vitamin C on Ptasma Lipid Level in Coronary Heart Disease Subjects

The effect of vitamin C therapy on plasma lipid levels was investigated in 39 patients with coronary heart disease and hyperlipemia, who were divided into four groups: Group A received 1.2g VC daily per os, Group B 0.6g VC/day, Group C 0.3g VC/day and Group D without VC supplement as control. Before and after receiving VC supplements at 15th day and 45th day blood Was sampled. Results revealed that Group A and Group B treated with oral vitamin C at 15th day slightly and 45th day significantly decreased the plasma lipid levels of total cholesterol, triglyceride and low density lipoproteinas as well increased the level of high density lipoprotein. The most significant effect on plasma lipid levels was observed in Group A (1.2g VC/day), but no apparent change in Group C (0.3g VC/day). All the coronary heart disease subjccts showed very low concentrations of ascorbic acid in blood, but it increased promptly after vitmin C therapy.