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Can blocking the Na/K exchange pump lead to a reduction in intracellular sodium?
Authors:I S Cohen
Abstract:It has been assumed that a rise in intracellular sodium should follow inhibition of the Na/K exchange pump. However, under certain conditions a reduction in intracellular sodium following pump blockage is possible. Many results postulating 'stimulation' of the Na/K exchange pump by low doses of the cardiac glycosides can be explained in this manner.
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