The influence of prostacyclin (PGI2) on contractile properties of isolated right ventricle of rat heart |
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| Authors: | M. Pavlović D. Petković M. Cvetković D. J. Macut K. Zdjelar M. Nešić O. Bosnić R. Radulović M. Mihajlović |
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| Affiliation: | 1. Institute of Physiology, Faculty of Medicine, University of Belgrade, Vi?egradska 26, P.O. Box 783, 11000, Belgrade, (Yugoslavia)
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| Abstract: | The mechanism of the positive inotropic effect of prostacyclin (PGI2) (2.6×10?6 mol/l) on the isolated right ventricle of rat heart was studied. Our results show that the positive inotropic effect of prostacyclin is produced indirectly through beta adrenoceptors and slow Ca2+ channels, because blockade of slow Ca2+ channels with verapamil (10?6 mol/l) and beta adrenoceptors with propranolol (10?6 mol/l) abolishes this effect. Alpha adrenoceptors do not mediate the action of PGI2. |
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