Chronic overcrowding decreases cytoplasmic free calcium levels in T lymphocytes of aged CBA/CA mice |
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Authors: | P Csermely I Pénzes S Toth |
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Institution: | 1. Institute of Biochemistry I, Semmelweis University, P.O. Box 260, H-1444, Budapest, (Hungary) 2. Department of Anesthesiology and Intensive Therapy, Semmelweis University, Budapest, (Hungary)
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Abstract: | Intracellular calcium concentration is a sensitive marker of the homeostasis of living cells, and its increase is an essential step of T lymphocyte activation. Changes in the environment provoke an adaptive stress-response of the organism. In our present work we have investigated the effect of chronic overcrowding on resting and lectin-stimulated cytoplasmic free calcium concentration of splenic T lymphocytes from young and aged CBA/CA mice (50 animals total). The animals were kept under ‘normal’ (68 cm2/animal) or ‘overcrowded’ (22 cm2/animal) conditions for 3 months. Young animals showed no change in resting and stimulated calcium after overcrowding. T cells from aged mice, however, displayed significantly smaller levels of both resting and lectin-stimulated intracellular calcium concentration (p<0.01 each), as compared to those of the non-stressed, aged animals. This inadequate adaptation in the calcium metabolism of T lymphocytes may significantly contribute to the diminished immune response of the aged in stress. |
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