| 抗生素与肠道菌群关系研究进展 |
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| 引用本文： | 李子艳,刘丽丽,毛艳艳,高柳滨. 抗生素与肠道菌群关系研究进展[J]. 科技导报(北京), 2017, 35(21): 26-31. DOI: 10.3981/j.issn.1000-7857.2017.21.002 |
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| 作者姓名： | 李子艳 刘丽丽 毛艳艳 高柳滨 |
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| 作者单位： | 中国科学院上海药物研究所信息中心, 上海 201203 |
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| 基金项目： | 中国科学院战略性先导科技专项（XDA12050201） |
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| 摘 要： | 从抗生素与肠道菌群的关系出发，在抗生素角度，概述了抗生素对肠道菌群构成、肠道定植抗力、菌群类别及代谢活动的影响，综述了抗生素通过调节肠道菌群恢复肠-脑轴、肠-肝轴稳态，延缓非感染性疾病的研究进展。在肠道菌群角度，简述了肠道菌群在抗生素耐药基因储存传播、新型抗生素发现过程中的特别作用。
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| 关 键 词： | 抗生素 肠道菌群 抗生素耐药基因 定植抗力 疾病 |
| 收稿时间： | 2017-08-30 |
Current research on the relationship between antibiotics and intestinal flora |
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| LI Ziyan,LIU Lili,MAO Yanyan,GAO Liubin. Current research on the relationship between antibiotics and intestinal flora[J]. Science & Technology Review, 2017, 35(21): 26-31. DOI: 10.3981/j.issn.1000-7857.2017.21.002 |
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| Authors: | LI Ziyan LIU Lili MAO Yanyan GAO Liubin |
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| Affiliation: | Intelligence Research Department, Information Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China |
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| Abstract: | Based on the relationship between antibiotics and intestinal flora, this paper summarizes the effects of antibiotics on intestinal flora composition, intestinal colonization resistance, flora and metabolic activities, and then explores antibiotics modulating the intestinal flora to restore the steady state of gut-brain axis or gut-liver axis for delaying the progress of diseases. In the perspective of intestinal flora, the paper briefs the special role of intestinal flora in antibiotic resistance gene storage and transmission, as well as new antibiotic discovery. Further research on the relationship between antibiotics and intestinal flora and their interactions will have a reference value on strategic use of antibiotics or alternative approach development for modulating intestinal flora. |
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| Keywords: | antibiotics intestinal flora antibiotic resistance genes colonization resistance disease |
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