Modification of membrane cholesterol content affects electrical properties and prolactin release of cultured pituitary cells |
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| Authors: | E Zyzek J P Desmazes D Gourdji B Dufy D Georgescauld |
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| Institution: | (1) INSERM U. 176, rue Camille Saint-Saëns, F-33077 Bordeaux, (France);(2) Centre de Recherche Paul Pascal, Talence, (France);(3) Collège de France, Paris, (France) |
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| Abstract: | Summary Treatment of cloned pituitary cells (GH3/B6) with cholesterol-enriched liposomes, which presumably increases membrane cholesterol content, affects the passive and active electrophysiological properties and stimulates the release of prolactin (PRL).Supported by grants from CNRS (ERA 493, ATP Endocrinologie). We thank NIAMDD for providing the reagents for PRL assay. |
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