Expression of multidrug resistance (mdr) gene(s) in primary lymphoid organs of chicken immune system during embryonic development |
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| Authors: | M. Petrini S. Galimberti A. Sabbatini F. Bianchi N. Bernardini A. Dolfi M. Lupetti |
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| Affiliation: | (1) Cattedra di Istologia ed Embriologia Istituto di Anatomia Umana normale, Via Roma 55, I-56100 Pisa, (Italy);(2) Cattedra di Ematologia Istituto di Clinica Medica, I, Via Roma, 67, I-56100 Pisa, (Italy);(3) Scuola Superiore di Studi e di Perfezionamento, Via Carducci, 44, I-56100 Pisa, (Italy) |
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| Abstract: | The presence of a multidrug resistance (MDR) related protein, P-170, in normal and pathological lymphoid cells has been described. The present report evaluates the expression of themdr 1 gene by using the reverse Polymerase Chain Reaction (PCR) on cells obtained from the thymus and bursa of chicken embryos starting from day 12 until hatching. Results show that the thymic cells are positive from day 12 to the end of the observation period. In contrast,mdr mRNA was detected in the bursa from day 14 to day 17 of embryonic life. Possible relationships between the expression ofmdr and the development of T and B lymphocytes are discussed. |
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| Keywords: | Chicken thymus bursa of Fabricius MDR mdr genes |
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