Molecular analysis of the association of HLA-B53 and resistance to severe malaria. |
| |
| Authors: | A V Hill J Elvin A C Willis M Aidoo C E Allsopp F M Gotch X M Gao M Takiguchi B M Greenwood A R Townsend |
| |
| Institution: | Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, UK. |
| |
| Abstract: | The protective association between the human leukocyte antigen HLA-B53 and severe malaria was investigated by sequencing of peptides eluted from this molecule followed by screening of candidate epitopes from pre-erythrocytic-stage antigens of Plasmodium falciparum in biochemical and cellular assays. Among malaria-immune Africans, HLA-B53-restricted cytotoxic T lymphocytes recognized a conserved nonamer peptide from liver-stage-specific antigen-1 (LSA-1), but no HLA-B53-restricted epitopes were identified in other antigens. These findings indicate a possible molecular basis for this HLA-disease association and support the candidacy of liver-stage-specific antigen-1 as a malaria vaccine component. |
| |
| Keywords: | |
|
|
