| pH响应性聚乙二醇-co-聚丙烯酸交联微球的合成 |
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| 引用本文： | 倪忠斌,张坤,朱雪艳,陈明清,刘晓亚,杨成.pH响应性聚乙二醇-co-聚丙烯酸交联微球的合成[J].江南大学学报(自然科学版),2006,5(6):730-733. |
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| 作者姓名： | 倪忠斌 张坤 朱雪艳 陈明清 刘晓亚 杨成 |
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| 作者单位： | 江南大学,化学与材料工程学院,江苏,无锡,214122 |
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| 基金项目： | 国家自然科学基金资助项目(50443012) |
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| 摘 要： | 在N,N′-亚甲基二丙烯酰胺(Bis)存在的条件下,以偶氮二异丁腈(AIBN)为引发剂,使苯乙烯单封端聚乙二醇(St-PEG)大分子单体与丙烯酸(AAc)在3-戊酮溶液中进行分散共聚反应,得到了聚乙二醇-co-聚丙烯酸(PEG-co-PAAc)交联微球.动态激光光散射测试结果表明,所得的交联微球具有良好的单分散性;同时发现,在共聚反应中St-PEG大分子单体、AAc和Bis溶液浓度对交联微球粒径有明显的影响;交联微球的Rh在pH为4.5附近突然增加,并在pH>7.0后保持不变,说明该PEG-co-PAAc交联微球具有明显的pH响应性.
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| 关 键 词： | 丙烯酸 聚乙二醇大分子单体 分散共聚 交联微球 pH响应性 |
| 文章编号： | 1671-7147（2006）06-0730-04 |
| 收稿时间： | 2005-11-15 |
| 修稿时间： | 2006-01-10 |
Preparation of Crosslinking Poly(Ethylene Glycol)-co-Poly(Acrylic Acid) Microspheres with pH-Responsive Properties |
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| NI Zhong-bin,ZHANG Kun,ZHU Xue-yan,CHEN Ming-qing,LIU Xiao-ya,YANG Cheng.Preparation of Crosslinking Poly(Ethylene Glycol)-co-Poly(Acrylic Acid) Microspheres with pH-Responsive Properties[J].Journal of Southern Yangtze University:Natural Science Edition,2006,5(6):730-733. |
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| Authors: | NI Zhong-bin ZHANG Kun ZHU Xue-yan CHEN Ming-qing LIU Xiao-ya YANG Cheng |
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| Institution: | School ot Chemical and Materials Engineering, Southern Yangtze University, Wuxi 214122, China |
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| Abstract: | The pH-responsive crosslinking poly(ethylene glycol)-co-poly(acrylic acid)(PEG-co-PAAc) microspheres were prepared by dispersion copolymerization of St-PEG macromonomer with acrylic acid in 3-pentanone in the present of N,N'-methylenebisacrylamide(Bis) as crosslinker and 2,2'-Azobis(isobutyronitrile)(AIBN) as initiator.The dynamic laser light scattering(DLS) measurement showed that the crosslinking microspheres have narrow size distribution.The effects of reaction parameters such as AAc concentration,PEG macromonomer concentration and Bis concentration on the R_h of obtained crosslinking microspheres were investigated.It was also found that the PEG-co-PAAc crosslinking microspheres behave excellent pH-responsive and exhibit a rapid increase in R_h when the pH value varies from about 4.5 to 7.0. |
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| Keywords: | acrylic acid St-PEG macromonomer dispersion copolymerization crosslinking microsphere pH-responsive |
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