Cholesterol mediates thyrotropin binding to liposomes containing gangliosides |
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| Authors: | S P Dufrane A Poss E Goormaghtigh J M Ruysschaert |
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| Institution: | (1) Laboratoire de Chimie-Physique des Macromolecules aux Interfaces, Université Libre de bruxelles, C.P. 206/2, B-1050 Bruxelles, Belgium |
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| Abstract: | Summary We present evidence that cholesterol mediates thyrotropin binding to liposomes containing GT1 ganglioside. Thyrotropin fixation is maximal at 22% of cholesterol. This result suggests that the gangliosides' organization in the lipid matrix modulates their interaction with the glycoprotein hormone. |
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