Checkpoint kinase 1 in DNA damage response and cell cycle regulation |
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Authors: | Mallikarjun Patil Navjotsingh Pabla Zheng Dong |
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Affiliation: | 1. Department of Cellular Biology and Anatomy, Georgia Regents University and Charlie Norwood VA Medical Center, 1459 Laney Walker Blvd., Augusta, GA, 30912, USA 3. Department of Pharmaceutical Sciences, St Jude Children’s Research Hospital, Memphis, Tennessee, USA 2. Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, 410022, Hunan, China
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Abstract: | Originally identified as a mediator of DNA damage response (DDR), checkpoint kinase 1 (Chk1) has a broader role in checkpoint activation in DDR and normal cell cycle regulation. Chk1 activation involves phosphorylation at conserved sites. However, recent work has identified a splice variant of Chk1, which may regulate Chk1 in both DDR and normal cell cycle via molecular interaction. Upon activation, Chk1 phosphorylates a variety of substrate proteins, resulting in the activation of DNA damage checkpoints, cell cycle arrest, DNA repair, and/or cell death. Chk1 and its related signaling may be an effective therapeutic target in diseases such as cancer. |
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