| 液质联用分析中药降糖制剂中掺入的西药成分 |
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| 引用本文： | 林艳萍,司端运,刘昌孝.液质联用分析中药降糖制剂中掺入的西药成分[J].天津大学学报(自然科学与工程技术版),2008,41(6):720-724. |
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| 作者姓名： | 林艳萍 司端运 刘昌孝 |
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| 作者单位： | [1]天津大学化工学院,天津300072 [2]天津药代动力学与药效动力学省部共建国家重点实验室,天津药物研究院,天津300193 |
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| 摘 要： | 采用液相色谱-离子阱质谱联用技术检测中药降糖制剂中非法掺入的西药成分．选用MGIIC18色谱柱，以甲醇、水和甲酸（三者的体积比为80．0：20．0：0．1）为流动相，对中药降糖制剂的提取液进行液相色谱-离子阱质谱分析．通过与对照品的色谱和质谱行为比较，对中药降糖制剂-荞芪胶囊中非法掺入的合成降糖药进行定性鉴别和初步定量分析．结果表明：该荞芪胶囊中分别检测到苯乙双胍2．6mg／粒，格列本脲2．0mg／粒；液相色谱-离子阱质谱联用技术快速、准确，可作为分析检测中药降糖制剂中非法掺入合成药的有效方法．
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| 关 键 词： | 液相色谱-质谱联用技术 中药降糖制剂 苯乙双胍 格列本脲 |
Detection of Synthetical Compounds Illegally Mixed into Traditional Chinese Medicine Antidiabetic Preparations by Liquid Chromatography-Mass Spectrometry |
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| LIN Yan-ping,SI Duan-yun,LIU Chang-xiao.Detection of Synthetical Compounds Illegally Mixed into Traditional Chinese Medicine Antidiabetic Preparations by Liquid Chromatography-Mass Spectrometry[J].Journal of Tianjin University(Science and Technology),2008,41(6):720-724. |
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| Authors: | LIN Yan-ping SI Duan-yun LIU Chang-xiao |
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| Institution: | LIN Yan-ping, SI Duan-yun, LIU Chang-xiao ( 1. School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China; 2. Tianjin State Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China ) |
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| Abstract: | Liquid chromatography-mass spectrometry was used to detect synthetical compounds illegally mixed into traditional Chinese medicine antidiabetic preparations. The organic extract of the traditional Chinese medicine antidiabetic capsule was analyzed through a Cl8 column with a mobile phase of methanol-formic acid （ 80.0 ： 20.0 ： 0.1 ） . Two components illegally added into the traditional Chinese medicine antidiabetic capsule were identified according to the chromatographic behavior and mass spectral data by comparison with those of reference substances. As a result, each capsule （ 400 mg ） for oral administration was quantited to contain 2.6 mg phenformin and 2.0 mg glibenclamide. The conclusion is that liquid chromatography-mass spectrometry can be used as a selective and sensitive instrumentality to detect compounds illegally mixed into the traditional Chinese medicine antidiabetic preparations. |
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| Keywords: | liquid chromatography-mass spectrometry traditional Chinese medicine antidiabetic preparations phenformin glibenclamide |
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