药物致急性肾衰竭36例临床分析

目的探讨药物性急性肾衰竭（ARF）的致病因素、临床表现、治疗等临床特点，提高药物性肾损害的诊治水平，加强临床用药的安全性。方法回顾性总结10年来我院收治的36例各种药物导致的ARF患者，从用药种类、年龄、临床表现、治疗及预后等进行分析。结果36例药物性ARF中，〉60岁的患者13例占36．11％。男性23例，女性13例。首位为抗菌素15例占41．67％，其次为中草药7例占19．44％。少尿型ARF25例，非少尿型11例。36例患者中没有1例死亡。结论药物性ARF临床上既可表现为少尿型也可表现为非少尿型ARF。临床用药应避免几种肾毒药同时使用，使用过程中应密切监测肾脏功能。在出现药物性ARF时，应尽早停药，并加强支持治疗。

The clinical analysis of 36 cases of drug-induced acute renal failure

Objectives： To comprehend the etidogy,chmcal features,treatment etc. ot drug renal injury , to improve its diagnosis and treatment level and enhance security of clinical medication. Methods： 36 cases of acute renal failure caused by drugs in our hospital from 1997 to 2007 were retrospectively reviewed and their medications,ages,etiologies,clinical features,treatment effects and prognosis were analyzed. Results：In 36 cases with acute renal failure caused by drugs, only 13 cases were elder than 60 years old （36.11%）. There were 23 males and 13 females .The main drug was antibiotic（ 15 , 41.67%）, the second was Chinese traditional herb （ 7, 19.44%） . oliguria type ARF was 25 cases and not-oliguria type 11 cases. There was no death in 36 cases. Conclusion： Drug-induced acute renal failure features oliguria type or not-oliguria type in clinic. Nephrotoxicity medicaments should be avoided using together and renal function should be monitored in the process of the use of nephrotoxicity medicaments. If medicaments should be stoped appears as soon as possible and supportive drug -induced ARF nephrotoxicity treatments strengthened.