外周血内VEGF水平对食管癌患者放化疗效果分析

目的观察外周血管内血管表皮生长因子(VEGF)含量对食管癌患者放化疗治疗效果的影响,并研究其变化与预后的关系.方法通过ELISA方法检测65例食管癌患者外周血中VEGF含量(25例健康志愿者作为对照),根据含量高低分为低VEGF组和高VEGF组,并对应检测放化疗后外周血中VEGF含量,分析起始VEGF含量以及变化对放化疗后1 a内的总生存和无进展生存的影响.结果放化疗后食管癌患者VEGF含量呈下降的趋势,由(105.7±11.0)ng/L降到(96.9±12.9)ng/L.低VEGF组与高VEGF组之间的1 a总生存率和1 a无进展生存率比较差异均无统计学意义(P0.05),而在VEGF含量升高或降低的不同变化中总生存率和无进展生存的差异均具有统计学意义(P0.05).结论降低外周血中VEGF含量能够明显提高患者的存活,检测外周血中VEGF的含量变化能够为预后提供预测和临床指导.

Analysis on the Effect of VEGF Level in Peripheral Blood in Esophageal Neoplasms Patients Accepted Chemoradiotherapy

Objective To detect the effects of vascular endothelial growth factor (VEGF) content in peripheral blood in the patients with esophageal neoplasms accepted chemoradiotherapy, and to investigate the relationship between prognosis and the alteration of VEGF contents before and after chemoradiotherapy. Method Peripheral blood VEGF concentrations of 65 patients with esophageal neoplasms were detected by ELISA method. According to the VEGF level, the patients were divided into two groups with 25 healthy volunteers as the control group. After chemoradiotherapy,the VEGF concentrations were detected again. The effects of original VEGF contents and the variations on one-year total survival and one-year progression free survival were analyzed. Results Chemoradiotherapy decreased VEGF level from (105. 7 ±11. 0) ng/L to (96. 9 ±12. 9) ng/L. The one-year total survival and one-year progression free survival were not associated with the original VEGF level of two groups(P>0. 05),but the differences were statistically between the VEGF increasing group and the decreasing group (P<0. 05). Conclusion Decreasing VEGF level can increase the survival rate, and monitoring the alteration of VEGF level can provide direction for clinical study and precaution for the cancer.