The effect of bradykinin on the electrical activity of rat jejunum |
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| Authors: | J. Hardcastle P. T. Hardcastle R. J. Flower P. A. Sanford |
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| Affiliation: | (1) Department of Physiology, Sheffield University, S10 2TN Sheffield;(2) Department of Pharmacology, Wellcome Research Laboratories, Beckenham, Kent;(3) Department of Physiology, The Middlesex Hospital Medical School, W1P 6DB London, (England) |
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| Abstract: | Summary Bradykinin increased the potential difference across both the jejunum and colon of the rat. This effect was significantly reduced by indomethacin, suggesting that it was mediated by prostaglandins. The possibility that bradykinin may contribute to the diarrhoea of the carcinoid syndrome by inducing a net secretory state in the intestine is discussed. |
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