Comparative ontogenesis of gamma-glutamyl transpeptidase in rat tissues |
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| Authors: | R. A. Wapnir V. J. Mancusi Lori A. Goldstein |
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| Affiliation: | (1) Department of Pediatrics, North Shore University Hospital, 11030 Manhasset, New York, USA;(2) Department of Pediatrics, Cornell University Medical College, 10021 New York, New York, USA |
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| Abstract: | Summary In rats, placental gamma glutamyl transpeptidase (GGTP) specific activity declined linearly during the last third of gestation. In contrast, the kidney enzyme activity progressively increased 15-fold. In the gut, peak activity was reached at mid-lactation (age 12 days). Hepatic GGTP levels were maximal during the foetal stage. Brain GGTP was negligible at birth and attained its highest specific activity at weaning.This work was supported in part by USPHS NIH SO8 RR-09128-03. |
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