脂肪组织血管重塑及其与慢性炎症的相互作用

肥胖机体胰岛素抵抗会引起血管并发症已得到认同，但新近关于肥胖机体慢性炎症的研究发现，在出现胰岛素抵抗前脂肪组织脉管系统已发生功能障碍。本研究分析脂肪组织毛细血管发生变化与缺氧的关系和缺氧与慢性炎症的关系，认为肥胖机体脂肪组织毛细血管发生变化，引起脂肪组织缺氧；缺氧诱导慢性炎症，肥胖关联的炎症又引起脂肪组织血管重塑，加剧脂肪组织功能障碍和胰岛素抵抗；提出在肥胖者体内，脂肪组织血管重塑能够调控慢性炎症和全身胰岛素敏感性。

Adipose Tissue Vascular Remodeling and Its Interactions with Chronic Inflammation

It is well known that vascular complication is a result of insulin resistance in obesity. Recent progress in the study of obesity-associated inflammation suggests that vasculature dysfunction occurs in adipose tissue before insulin resistance. Analyzing the relationship between adipose tissue vascular remodeling and hypoxia as well as the relationship between hypoxia and chronic inflammation, this paper concludes that adipose tissue vascular remodeling will cause adipose tissue hypoxia which causes chronic inflammation, and in turn chronic inflammation causes vascular remodeling, fat tissue dysfunction and insulin resistance. This paper proposes that vascular remodeling of adipose tissue can regulate and control hypoxia and systemic insulin sensitivity.