| 丁香苦苷血浆蛋白结合率的测定 |
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| 引用本文： | 李秋红,崔明宇,隋晓璠,李永吉. 丁香苦苷血浆蛋白结合率的测定[J]. 哈尔滨商业大学学报(自然科学版), 2008, 24(2): 148-150 |
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| 作者姓名： | 李秋红 崔明宇 隋晓璠 李永吉 |
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| 作者单位： | 黑龙江中医药大学,药学院,哈尔滨,150040 |
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| 基金项目： | 黑龙江省科技厅留学归国基金 , 黑龙江省教育厅海外学人科研(合作)基金 |
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| 摘 要： | 测定丁香苦苷的血浆蛋白结合率.采用超速离心法除掉血浆蛋白,高效液相色谱法对高、中、低剂量给药后的丁香苦苷血药质量浓度进行测定.高、中、低剂量丁香苦苷的血浆蛋白结合率分别为50.81%,56.92%,57.28%.丁香苦苷血浆蛋白结合率不具有质量浓度依赖性,不易引起具有药理作用的游离型血药质量浓度发生明显变化,保证丁香苦苷临床用药有较好的安全性.
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| 关 键 词： | 丁香苦苷 血浆 蛋白结合率 超速离心法 |
| 文章编号： | 1672-0946(2008)02-0148-03 |
| 修稿时间： | 2007-06-24 |
Determination of protein bound fraction of serum of syringopicroside |
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| LI Qiu-hong,CUI Ming-yu,SUI Xiao-fan,LI Yong-ji. Determination of protein bound fraction of serum of syringopicroside[J]. Journal of Harbin University of Commerce :Natural Sciences Edition, 2008, 24(2): 148-150 |
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| Authors: | LI Qiu-hong CUI Ming-yu SUI Xiao-fan LI Yong-ji |
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| Affiliation: | LI Qiu-hong,CUI Ming-yu,SUI Xiao-fan, LI Yong-ji (School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150040, China) |
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| Abstract: | To determinate the protein-bound fraction of syringopicroside in serum. The part serum is obtained by ultracentrifuge for determination of unbound fraction of the drug. Syringopicroside levels in serum are detected by HPLC after injection of low, medium and highdose. The bound fraction of syringopicroside to serum protein is 50. 81% ,56.92% ,57.28% respectively at different doses. It would not made the obvious change of free fraction with pharmacological action that the protein binding of syringopicroside is not dependent on the doses. It is suggested that the above results may ensure to have safety of syringopicroside in clinic. |
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| Keywords: | syringopicroside serum protein-bound fraction ultracentrifuge |
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