Cardiotonic activities of some new type of bufadienolide- and cardenolide-conjugates

Summary Some new type of bufadienolide-and cardenolide-conjugates, including bufotoxins and 3-sulfates recently isolated from the toad skin, were tested for their cardiotonic activities by using isolated frog hearts and guinea-pig atria. The relative potencies were obtained and reported.This study was reported at the 49th General Meeting of theJapanese Pharmacological Society, 31 March 1976, Osaka. The authors are grateful to Prof. T. Nambara, Pharmaceutical Institute, Tohoku University, Sendai, for his kind supply of the compounds used in this study.