| 肠出血性大肠埃希菌O157:H7紧密黏附素C300与LTB融合蛋白B细胞表位预测 |
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| 引用本文： | 崔莎莎,徐松宝,姜岩硕,李明成. 肠出血性大肠埃希菌O157:H7紧密黏附素C300与LTB融合蛋白B细胞表位预测[J]. 北华大学学报(自然科学版), 2011, 0(3): 296-299 |
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| 作者姓名： | 崔莎莎 徐松宝 姜岩硕 李明成 |
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| 作者单位： | 北华大学医学检验学院;吉林化学工业股份有限公司总医院第一医院; |
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| 基金项目： | 吉林省科技发展计划项目(20080513) |
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| 摘 要： | 目的 对肠出血性大肠埃希菌O157:H7紧密黏附素C300与黏膜佐剂不耐热肠毒素(LTB)融合蛋白二级结构及B细胞识别表位进行预测,为开发新型疫苗提供理论依据.方法 采用DNA star软件中的Protean预测软件对Intimin C300与LTB融合蛋白的亲水性指数、β-转角、柔韧性、表面可及性和抗原指数进行预测....
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| 关 键 词： | 肠出血性大肠埃希菌 紧密黏附素C300 融合蛋白 B细胞识别表位 |
Predication of the Secondary Structure and B Cell Epitopes for the Fusion Protein of Intimin C300 and LTB in EHEC O157:H7 |
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| CUI Sha-sha,XU Song-bao,JIANG Yan-shuo,LI Ming-cheng. Predication of the Secondary Structure and B Cell Epitopes for the Fusion Protein of Intimin C300 and LTB in EHEC O157:H7[J]. Journal of Beihua University(Natural Science), 2011, 0(3): 296-299 |
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| Authors: | CUI Sha-sha XU Song-bao JIANG Yan-shuo LI Ming-cheng |
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| Affiliation: | CUI Sha-sha1,XU Song-bao2,JIANG Yan-shuo1,LI Ming-cheng1 (1.Medical Inspection College of Beihua University,Jilin 132013,China,2.The First Hospital of Jilin Chemical Industry Co.Ltd,Jilin 132015,China) |
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| Abstract: | Objective To predict the secondary structure and B cell epitopes for the fusion protein of Intimin C300 and LTB in EHEC O157:H7 to provide some evidences for developing a new type of the vaccine.Method The secondary structure of Intimin C300 and LTB was predicted by the methods of Garnier-Robson,Chou-Fasman and Karplus-Schplus,and hydrophilicity,surface probability and antigenic index were obtained by the methods of Hopp-Woods,Emini and Jameson-wolf respectively.Meanwhile,the B cell epitopes for fusion prot... |
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| Keywords: | EHEC O157:H7 intimin C300 fusion protein B cell epitopes |
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