| 胆碱脂酶催化反应的量子化学研究——氨基酸残基间氢键问题的计算与讨论 |
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| 引用本文： | 黄敬安,苏忠民,席大勇,崔瑞海. 胆碱脂酶催化反应的量子化学研究——氨基酸残基间氢键问题的计算与讨论[J]. 东北师大学报(自然科学版), 1990, 0(3) |
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| 作者姓名： | 黄敬安 苏忠民 席大勇 崔瑞海 |
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| 作者单位： | 东北师大化学系，东北师大化学系，东北师大化学系，哈尔滨师专 |
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| 摘 要： | 本文对胆碱脂酶脂解部位的组氨酸、丝氨酸等残基间的氢键问题做了CNDO/2的量子化学计算,从理论上讨论了乙酰胆碱酶催化水解反应中谁作为亲核基团向底物进攻的问题,得到一些有益的结果。
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| 关 键 词： | 胆碱脂酶 酶催化 氢键 CNDO/2 |
QUANTUM CHEMISTRY STUDY OF CHOLINESTERASE:THE COMPUTATION AND DISCUSSION OF THE HYDROGEN BONDING BETWEEN HISTICLINE AND SERINE RESIDUS |
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| Huang Jingan Su Zhongmin Xi Dayong Cui Ruihai. QUANTUM CHEMISTRY STUDY OF CHOLINESTERASE:THE COMPUTATION AND DISCUSSION OF THE HYDROGEN BONDING BETWEEN HISTICLINE AND SERINE RESIDUS[J]. Journal of Northeast Normal University (Natural Science Edition), 1990, 0(3) |
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| Authors: | Huang Jingan Su Zhongmin Xi Dayong Cui Ruihai |
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| Affiliation: | Huang Jingan Su Zhongmin Xi Dayong Cui Ruihai |
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| Abstract: | In this papert,we conducted the quantum chemistry calculation (CNDO/2) to the hydrogen bonding between histicline and serine residues of the cholinesterase ester degradation sites.From the theoretical point of view,we discussed which of the nucleopophilic group that attacts the substrate in the acetylcholine catalized hydrolysis reaction,and we obtained some meaningful results. |
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| Keywords: | Choline trase Enzyme Catalization Hydrogen bonding CNDO/2 |
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