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Hemmung der Phosphodiesterase aus Rattenherzen durch Intensain |
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| Authors: | R. E. Nitz E. Schraven D. Trottnow |
| Affiliation: | (1) Medizinisch-Biologische Forschungsabteilung der Cassella Farbwerke Mainkur AG, 6 Frankfurt a. M.-Fechenheim, Deutschland |
| Abstract: | Summary Intensain causes in vitro a significant and apparently competitive inhibition of phosphodiesterase, which transforms the 3 ,5-AMP to 5-AMP. These results explain some intensain effects, especially the period of latency to reach the maximum effect, the inotropic action and its reaction under the influence of -blocking and-stimulating agents10–13.3-( -Diäthylamino-äthyl)-4-methyl-7-carbäthoxy-methoxy-2-oxo-(1,2-chromen), Carbochromen. |
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