| ~（35）S－MAbSZ39在荷瘤鼠体内药代动力学研究 |
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| 引用本文： | 孙志方,黄强,兰青,杜子威. ~（35）S－MAbSZ39在荷瘤鼠体内药代动力学研究[J]. 实验动物科学, 1996, 0(3) |
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| 作者姓名： | 孙志方 黄强 兰青 杜子威 |
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| 作者单位： | 苏州医学院附属第二医院脑肿瘤研究室 |
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| 摘 要： | 以￣（３５）Ｓ标记抗人脑胶质瘤单克隆抗体ＳＺ３９制备成免疫导向放疗剂，在荷人脑胶质瘤裸小鼠体内药代动力学符合三室线性模型，总药时方程为Ｃ＿ｔ＝１５５９２７６ｅ￣（─３．４９ｔ）＋９７７３１３ｅ￣（－０．５ｔ）＋２１６８２ｅ￣（－０．０１７ｔ），Ｔ１／２ａ为０．２３ｈ，Ｔ１／２β为１．４Ｇｈ，Ｔ１／２γ为４２．９ｈ。体内分布研究表明￣（３５）Ｓ－ＭＡｂＳＺ３９可特异性浓聚于胶质瘤，在正常组织中无明显蓄积，发挥了单抗导向的高选择性作用，在给药后第五天，与￣（３５）Ｓ－ｎｌｇＧ及￣（３５）Ｓ相比，特异指数分别为４．１和４．８７，具有显著优越性（Ｐ＞０．０５）。结果揭示３５Ｓ－ＭＡｂＳＺ３９有望作为一种高效低毒的导向放疗制剂应用于胶质瘤治疗，以一周间隔多疗程治疗方案为佳。
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| 关 键 词： | ￣（35）S，胶质瘤，单克隆抗体，裸小鼠，药代动力学 |
Pharmacokinetics study of 35S-Monoclonal antibody SZ39 against glioma in tumor-bearing nude mice |
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| Sun Zhifang,Huang Qiang, Lan Qing, Du Ziwei Brain Tumor Research Department,Second Affiliated Hospital Suzhou Medical College [. Pharmacokinetics study of 35S-Monoclonal antibody SZ39 against glioma in tumor-bearing nude mice[J]. Laboratory Animal Science, 1996, 0(3) |
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| Authors: | Sun Zhifang Huang Qiang Lan Qing Du Ziwei Brain Tumor Research Department Second Affiliated Hospital Suzhou Medical College [ |
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| Affiliation: | Sun Zhifang,Huang Qiang, Lan Qing, Du Ziwei Brain Tumor Research Department,Second Affiliated Hospital Suzhou Medical College 215004[ |
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| Abstract: | |
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| Keywords: | glioma pharmacokinetics |
| 本文献已被 CNKI 等数据库收录！ |
