| 类P3L在痴呆动物模型确立中的作用 |
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| 引用本文： | 王跃春,王子栋.类P3L在痴呆动物模型确立中的作用[J].暨南大学学报,1999,20(4):4-6. |
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| 作者姓名： | 王跃春 王子栋 |
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| 作者单位： | 暨南大学医学院生理学教研室!广东广州510632 |
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| 基金项目： | 广东省卫生系统“五个一科教兴医工程”；国力院侨办重点课题科研基金 |
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| 摘 要： | 目的：探讨类Ｐ３Ｌ在痴呆动物模型确立中的作用。方法：用外科手术切断大鼠左侧穹窿－海马伞（ＦＦ）的方法建立Ａｌｚｈｅｉｍｅｒ病（ＡＤ）大鼠模型，于莫有后对其进行迷宫检查和类Ｐ３伏期（类Ｐ３Ｌ）测定。结果：ＡＤ大鼠类Ｐ３Ｌ较对照组有显著延长，并与迷宫试验指标错误反应次数（ＥＮ）增多及总反应时间（ＴＲＴ）处宅呈正相关。结论：类Ｐ３Ｌ为痴呆动物模型的确立提供了一个较为客观而可行的电生理指标。
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| 关 键 词： | 类P3L 迷宫 痴呆 动物模型 Alzheimer病 |
The role of P3-Like latency in the determination of demented animal models |
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| WANG Yao-chun,WANG Zi-dong,LIN Xing-hui.The role of P3-Like latency in the determination of demented animal models[J].Journal of Jinan University(Natural Science & Medicine Edition),1999,20(4):4-6. |
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| Authors: | WANG Yao-chun WANG Zi-dong LIN Xing-hui |
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| Abstract: | Aim: To study the role of P3-like latency in the determination of demented animal models. Methods: a model was established by unilateral fimbrial-fornix (FF) transection in rat. Then, Y-type maze test and elicitation of P3-like latency were carried out separately before and after the AD models were built. Results: P3-like latency in AD rats were prolonged statistically as compared with the controls and had postive correlation with indices of Y-maze test(EN, TRT). Conclusion: P3-like latency provided an objective and feasible index of electrical physiology for us to determine whether a demented model has been established. |
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| Keywords: | P3-like Latency Y-Maze test dementia |
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