| 黑龙江省实验小鼠、大鼠遗传学质量调查 |
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| 引用本文： | 韩凌霞,刘霄磊,蔡文博,李行,司昌德,曲连东.黑龙江省实验小鼠、大鼠遗传学质量调查[J].实验动物科学,2010,27(5):19-22,48. |
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| 作者姓名： | 韩凌霞 刘霄磊 蔡文博 李行 司昌德 曲连东 |
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| 作者单位： | 中国农业科学院哈尔滨兽医研究所实验动物中心,哈尔滨15001 |
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| 摘 要： | 目的根据最新颁布的国家标准,对黑龙江省的实验小鼠、大鼠的遗传学质量进行调查。方法参照国家标准《实验动物近交系小鼠、大鼠生化标记检测方法》GB/T 14927.1-2008,应用乙酸纤维素板,对来自4个单位的BALB/c和C57BL/6实验小鼠及3个单位的SD和Wistar实验大鼠进行生化标记位点的检测。结果被检的BALB/c小鼠和大鼠中均存在杂合。结论大鼠符合封闭群遗传概貌,但近交系小鼠出现了遗传漂变。
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| 关 键 词： | 生化标记 实验大鼠 实验小鼠 国家标准 |
Investigation of the Genetic Quality of Laboratory Mice and Rats in Heilongjiang Province |
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| HAN Ling-xia,LIU Xiao-lei,CAI Wen-bo,LI XING,SI Chang-de,QU Lian-dong.Investigation of the Genetic Quality of Laboratory Mice and Rats in Heilongjiang Province[J].Shiyan Dongwu Kexue,2010,27(5):19-22,48. |
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| Authors: | HAN Ling-xia LIU Xiao-lei CAI Wen-bo LI XING SI Chang-de QU Lian-dong |
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| Institution: | (Laboratory Animal Center of Harbin Veterinary Research Institute,CAAS,Harbin 150001,China) |
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| Abstract: | Objective To investigate the genetic quality of laboratory mice and rats in Heilongjiang Province in 2009.Method According to the national standard GB/T 14927.1-2008,Laboratory Animal-Genetic Monitoring： Methods for Biochemical Markers of Inbred mice and rats,biochemical markers were detected in mice,BALB/c and C57BL/6 strains,and rats,SD and Wistar stocks,from different sources.Results Heterozygous loci were detected in BALB/c mice and the two rat stocks.Conclusion The rats in our province are in accordance with the genetic profile of closed colony,however genetic drift may occur in mice. |
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| Keywords: | Biochemical marker Rats Mice National standard |
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