| 11－脱氧甘草次酸衍生物的合成（Ⅱ） |
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| 引用本文： | 彭宇,韩永生,王彩兰,冯瑞.11－脱氧甘草次酸衍生物的合成（Ⅱ）[J].河南师范大学学报(自然科学版),1994(1). |
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| 作者姓名： | 彭宇 韩永生 王彩兰 冯瑞 |
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| 作者单位： | 河南师范大学化学系 |
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| 摘 要： | 用甘草次酸还原制得１１－脱氧甘草次酸，以此为原料分别与乙酸酐、丙酸酐、顺丁烯二酸酐、正己酸酐和邻苯二甲酸酐反应生成酯，再分别同金属化合物反应制得１２种１１－脱氧甘草次酸酯类和盐类衍生物，具有潜在的药理活性和应用前景。用ＩＲ、ＨＮＭＲ、ＭＳ和元素分析确证了它们的结构，并对其光谱性质进行了讨论．
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| 关 键 词： | 甘草次酸 11－脱氧甘草次酸 酸酐 酯 合成 |
Syntbesis of 11-Deoxoglycyrrbetinic Acid Derivatives |
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| Peng Yu Han Yongsheng Wang Cailan Feng Rei.Syntbesis of 11-Deoxoglycyrrbetinic Acid Derivatives[J].Journal of Henan Normal University(Natural Science),1994(1). |
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| Authors: | Peng Yu Han Yongsheng Wang Cailan Feng Rei |
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| Abstract: | Twelve 3-esterified and its salts derivatives were readily prepared from11-deoxoglycyrrhetini acid with the appropriate acylation regents such as acetic anhydride,propionicanhydrids,preferably in the presence of a suitable solvent and at an elevated temperature,than,reactwith the basic metal compounds.These derivatives possess interesting and unexpected pharmaceuticalproperties.Their struetures were confirmed by IR,HNMR,MS and elemental analysis. |
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| Keywords: | glycyrrhetinic acid 11-deoxoglyeyrrhetinic acid anhydride synthesis esters |
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