两种给药途径注射吗啡对大鼠CCI模型的影响

通过建立坐骨神经慢性挤压伤模型（Chronic Constriction Injurymodel，CCI模型），运用鞘内和腹腔给药技术，对比了2种给药途径单次注射不同剂量的吗啡对CCI大鼠机械性缩足反射阈值（MWT）的影响．结果显示，单次鞘内注射吗啡1μg·kg^-1，给药后1h和3h，在大鼠CCI模型上的镇痛作用与单次腹腔注射吗啡1mg·kg^-1的镇痛作用相当，与单次腹腔注射吗啡0．5mg·kg^-1和0．1mg·kg^-1的镇痛作用具有显著性差异（P〈0．05）．这表明鞘内注射吗啡在大鼠CCI镇痛模型上具有用量小、效果好等优点，对于筛选产量小、难提取，但作用效果明显的镇痛药物具有明显的优越性．

Effects of Morphine Injected by Two Routes on Chronic Constriction Injury (CCI) Rat Model

In our report, Chronic Constriction Injury （CCI） rat model was established, intrathecal catheteriza-tion （ i. t. ） and intraperitoneal injection （ i. p. ） were employed, and the effects of two routes with different doses of morphine on MWT of CCI rats were compared. The results indicated that the morphine group of single i. p. （ 1 mg·kg^-1 ） after 1 h, 3 h treatments have similar analgesic effects with the morphine groups of single i. t. （ 1 μg·kg^-1 ）, however, there are significamg ~ kg- 1nt differences （P 〈 0.05 ） between the morphine group of single i. p. （ 1mg·kg^-1 ） after 1 h, 3 h treatments and the morphine group of single i.p. doses of 0.5 mg·kg^-1 and 0.1 mg·kg^-1 body weight, which suggested that the intrathecal catheterization （ i. t. ） injection of morphine in-to Chronic Constriction Injury （CCI） rat model has the advantages of small dosage and better effects, and which could be used for screening drugs which are difficult to be extracted.