Ergot alkaloids and phosphodiesterase; ‘in vitro’ activities in several rat brain areas |
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| Authors: | P Venutti C Ferretti P Portaleone |
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| Institution: | (1) Institute of Pharmacology, University of Turin, Corso Raffaello 30, I-10125 Turin, (Italy) |
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| Abstract: | Summary The ‘in vitro’ activity of ergotamine, dihydroergocristine, dihydroergocornine and dihydroergocryptine on the phosphodiesterase
system at low and high Km in several rat brain areas was examined. These drugs were found to exert an inhibitory effect in all the areas examined with
regard to both systems, and particularly on low substrate concentration phosphodiesterases.
Acknowledgments. Ergot alkaloids were a generous gift of Poli Industria Chimica, Milan. |
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