潜伏梅毒的临床特点与血清学分析

目的 总结CO2潜伏梅毒患者的临床特点,分析其血清学检测结果。方法 回顾性分析2001年1月至2007年11月在北京协和医院皮肤科性病中心诊治的601例潜伏梅毒患者的临床资料。结果 601例潜伏梅毒患者中,早期潜伏梅毒174例,晚期潜伏梅毒170例,不能确定病期的潜伏梅毒257例;男256例,女345例,男∶女为0.74∶1;20～39岁高发,主要传染来源为非婚性接触;46例(7.65%)合并其他性传播疾病;251例（41.76%）因其他性病或疑有性病进行检查时确诊。早期潜伏梅毒、晚期潜伏梅毒和不能确定病期潜伏梅毒患者中血浆反应素环状卡片试验(RPR)滴度大于1∶8的患者比例分别为72.99%(127/174)、52.94%(90/170)和60.31%(155/257)。早期潜伏梅毒患者治疗l2个月后的RPR阴转率明显低于早期显性梅毒患者(P=0.044)。结论 应加强梅毒宣传力度,多渠道筛查以控制梅毒。

Clinical Features and Serologic Analysis of Latent Syphilis

Objective To summarize the clinical features and analyze the serologic test results of latent syphilis. Methods The clinical data of 601 patients with latent syphilis who were treated in the sexually transmitted disease centre of Peking Union Medical College Hospital between January 2001 and November 2007 were retrospectively analyzed. Results Of the 601 cases of latent syphilis,there were 174 cases of early latent syphilis(EL),170 cases of late latent syphilis(LL),and 257 cases of unknown latent syphilis. Male to female ratio was 0.74:1（256 males and 345 females,respectively). Patients aged 20-39 years accounted for the largest proportion. Non-marital sexual intercourse was the main route of infection. Forty-six patients (7.65%) were co-infected with other sexually transmitted diseases. A total of 251 cases of latent syphilis (41.76%) were confirmed when the patients were receiving tests for other sexually transmitted diseases or suspected sexually transmitted diseases. Of the 601 patients with EL,LL and unknown latency,the proportion of serum rapid plasma reagin(RPR) titers higher than or equal to 8 were 72.99% (127/174),52.94% (90/170),and 60.31%(155/257),respectively. Compared with the early syphilis,serological negative conversion rate was significantly lower after treatment for l2 months in the early latent syphilis patients (P=0.044). Conclusion Education and awareness raising on syphilis should be strengthened to lower the prevalence of latent syphilis.