Interaction of chlorpromazine with organic solvents and fatty acids as studied by UV-spectrophotometry |
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Authors: | M H Bickel J Römer |
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Institution: | (1) Department of Pharmacology, University of Berne, Friedbühlstr. 49, CH-3000 Berne, (Switzerland) |
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Abstract: | Summary The magnitude of the UV-spectral change of chlorpromazine increases in the presence of increasing concentrations of alcohols or fatty acids and with increasing chain length. A maximum is reached with 14.0- or 16.0-fatty acids. The difference spectrum is still larger with unsaturated fatty acids, a maximum effect being obtained with one cis-double bond. The spectral change is abolished by chaotropic and enhanced by antichaotropic agents.Supported by a grant of the Swiss National Science Foundation. |
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