| 基于TRPM8通道薄荷醇对小鼠气道平滑肌影响的实验研究 |
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| 引用本文： | 郅琳,臧文华,张雪鹏,胡久略. 基于TRPM8通道薄荷醇对小鼠气道平滑肌影响的实验研究[J]. 科学技术与工程, 2019, 19(5) |
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| 作者姓名： | 郅琳 臧文华 张雪鹏 胡久略 |
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| 作者单位： | 南阳理工学院张仲景国医国药学院,南阳理工学院张仲景国医国药学院,南阳理工学院张仲景国医国药学院,南阳理工学院张仲景国医国药学院 |
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| 摘 要： | 目的：基于TRPM8通道研究薄荷醇(Menthol)对小鼠气道平滑肌的影响。方法：运用平滑肌张力测定技术检测Menthol对TRPM8野生型(TRPM8+/+)和敲除型(TRPM8-/-)小鼠离体气道平滑肌的张力改变。结果：1. Menthol呈浓度依赖性地引起TRPM8+/+小鼠气道平滑肌舒张,而在TRPM8-/-小鼠此作用不明显。结论：Menthol可通过TRPM8通道改变小鼠气道平滑肌张力
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| 关 键 词： | TRPM8通道 Menthol |
| 收稿时间： | 2018-09-29 |
| 修稿时间： | 2018-12-04 |
Study of menthol on mice based on TRPM8 channelsEffect of airway smooth muscle |
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| ZHI Lin,ZANG Wenhu,ZHAGN Xuepeng and Hu Jiulve. Study of menthol on mice based on TRPM8 channelsEffect of airway smooth muscle[J]. Science Technology and Engineering, 2019, 19(5) |
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| Authors: | ZHI Lin ZANG Wenhu ZHAGN Xuepeng Hu Jiulve |
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| Abstract: | Objective: To study the effect of menthol (Menthol) on airway smooth muscle in mice based on TRPM8 channel. METHODS: The tension of isolated airway smooth muscle of TRPM8 wild type (TRPM8+/+) and knockout type (TRPM8-/-) mice was measured by measuring the tension of Menthol. Menthol induced the relaxation of airway smooth muscle in TRPM8+/+ mice in a concentration-dependent manner, but not in TRPM8-/- mice. Conclusion: Menthol can change the airway smooth muscle tension through TRPM8 channel. |
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| Keywords: | TRPM8 channel Menthol |
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