| 水相合成3-羧甲基-5，5-二苯基海因的绿色工艺 |
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| 引用本文： | 王敏,赵蕊池,宋志国,刘洋.水相合成3-羧甲基-5，5-二苯基海因的绿色工艺[J].渤海大学学报(自然科学版),2013(3):280-283. |
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| 作者姓名： | 王敏 赵蕊池 宋志国 刘洋 |
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| 作者单位： | [1]渤海大学化学化工与食品安全学院,辽宁锦州121013 [2]渤海大学实验管理中心,辽宁锦州121013 |
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| 基金项目： | 辽宁省教育厅资助项目（No：L2011198）,2012年地方高校国家级大学生创新训练计划项目（No：201210167024） |
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| 摘 要： | 以5，5-二苯基乙内酰脲为起始原料，在碱性条件下，经一步法合成重要的化工原料3-羧甲基-5，5-二苯基海因．通过考察碱的种类、5，5-二苯基乙内酰脲用量和回流反应时间对产率的影响，确定较佳工艺条件为：5，5-二苯基乙内酰脲与氯乙酸钠摩尔比为1：1．1，在氢氧化钠水溶液中回流反应3h，可得到产率为68％的高纯度3-羧甲基-5，5-二苯基海因．产品结构经IR、1HNMR．13CNMR及MS进行了表征．
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| 关 键 词： | 3-羧甲基-5，5-二苯基海因 5，5-二苯基乙内酰脲 碱 水相合成 |
A green procedure for the synthesis of 3 - carboxylmethyl - 5,5 - diphenyl hydantoin in water |
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| WANG Min,ZHAO Rui -chi,SONG Zhi -guo,LIU Yang.A green procedure for the synthesis of 3 - carboxylmethyl - 5,5 - diphenyl hydantoin in water[J].Journal of Bohai University:Natural Science Edition,2013(3):280-283. |
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| Authors: | WANG Min ZHAO Rui -chi SONG Zhi -guo LIU Yang |
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| Institution: | College of Chemistry, Chemical Engineering and Food Safety, Bohai University, Jinzhou 121013 (2. Management Center for Experiment, Bohai University, Jinzhou 121013, China) |
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| Abstract: | An important chemical material, 3 -carboxylmethyl -5,5 -diphenyl hydantoin was synthesized by one - step using 5,5 - diphenyl hydantoin as a raw material in the presence of alkali. The effects of alkalis, amounts of 5,5 -diphenyl hydantoin, and refluxing time on the yields were investigated. The optimal conditions were as follows： the molar ratio of 5,5 -diphenyl hydantoin to sodium monochloroacetate was 1 ： 1.1, refluxing for 3 h in sodium hydroxide solution, and 3 -carboxylmethyl -5,5 -diphenyl hydantoin with high purity was ob- tained in 68% yield. The product was characterized by IR, 1H NMR, 13C NMR and MS. |
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| Keywords: | 3 - carboxylmethyl - 5 5 - diphenyl hydantoin 5 5 - diphenyl hydantoin alkali synthesis in water |
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