Hierarchical porous calcium carbonate microspheres as drug delivery vector |
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| Authors: | Hui Yang Yunfeng Wang Tongxiang Liang Yiqun Deng Xiaopeng Qi Honghui Jiang Yangjun Wu Huichang Gao |
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| Affiliation: | School of Materials Science and Engineering, Jiangxi University of Science and Technology, Ganzhou 341000, China,School of Materials Science and Engineering, Jiangxi University of Science and Technology, Ganzhou 341000, China,School of Materials Science and Engineering, Jiangxi University of Science and Technology, Ganzhou 341000, China,School of Materials Science and Engineering, Jiangxi University of Science and Technology, Ganzhou 341000, China,School of Materials Science and Engineering, Jiangxi University of Science and Technology, Ganzhou 341000, China,School of Materials Science and Engineering, Jiangxi University of Science and Technology, Ganzhou 341000, China,School of Materials Science and Engineering, Jiangxi University of Science and Technology, Ganzhou 341000, China and School of Medicine, South China University of Technology, Guangzhou, 510641, China |
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| Abstract: | CaCO3 crystals with different hierarchical structure were fabricated by the precipitation of CaCO3 in an aqueoussolution containing guar gum (GG). Through adjusting a range of parameters, the size distribution and microstructureof CaCO3 were well controlled. Results showed that GG facilitated the formation of the hierarchicalhollow sphere through assembling of nanocrystals, while inhibited the growth of CaCO3 crystals and restrainedphase transition from calcite to vaterite at high concentration of GG (CGG) condition; Moreover, increasingreaction temperature led to larger particles and stable crystalline phase formed. According to the results, amorphology map was presented. Furthermore, Drug loading and releasing results ensured porous CaCO3 microspheresa promising vector for drug delivery. |
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| Keywords: | Calcium carbonateMicrospheresPhase transformationMorphology-controlled growthBiomedical application |
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