Spontaneous reversal of ethinyl estradiol-induced cholestasis in the rat |
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| Authors: | R. Tritapepe C. Di Padova Paola Rovagnati |
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| Affiliation: | (1) 1st Surgical Clinic, University of Milan School of Medicine, Via F. Sforza, 35, I-20122 Milan, (Italy);(2) Present address: 3rd Medical Clinic, University of Milan School of Medicine, Via Pace, 15, I-20122 Milan, (Italy) |
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| Abstract: | Summary The spontaneous reversal of ethinyl estradiol-induced cholestasis has been documented 7 days after the last estrogen administration in the rat. This finding supports the hypothesis that estrogens produce only a transient functional failure of the hepatocytic structures responsible for bile secretion.Supported by Research grant CT-77, 0153304 from Consiglio Nazionale delle Ricerche, Rome, Italy. |
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