| 褪黑素的抗羰基应激作用 |
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| 引用本文： | 李国林,贺洪,彭密军,蔡建光,印大中.褪黑素的抗羰基应激作用[J].湖南师范大学自然科学学报,2007,30(3):99-104,109. |
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| 作者姓名： | 李国林 贺洪 彭密军 蔡建光 印大中 |
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| 作者单位： | 湖南师范大学生命科学学院,蛋白质化学与发育生物学教育部重点实验室,中国,长沙,410081 |
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| 基金项目： | 国家科技计划863资助项目(2007AA02Z433)，湖南省科技计划重点资助项目(06FJ3001)，湖南师范大学博士启动基金资助项目(53112-1392)，湖南师范大学青年基金资助项目(53112-1184) |
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| 摘 要： | 从化学反应体系探讨褪黑素(MT)对机体内普遍存在的自由基氧化和非酶糖基化重要活性中间产物——丙二醛(MDA)的清除作用,进而探讨MT对血液的MDA羰基应激体系的影响,结果表明:MT不仅能直接清除MDA,而且能抑制MDA等毒性羰基类物质诱导的血液粘度的升高;这表明,MT抗氧化活性的分子机制可能是抗羰基应激.
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| 关 键 词： | 褪黑素 羰基应激 丙二醛 血液粘度 |
| 文章编号： | 1000-2537（2007）03-0099-06 |
| 修稿时间： | 2007-01-03 |
Inhibiting Effects of Melatonin on Carbonyl Stress |
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| LI Guo-lin,HE Hong,PENG Mi-jun,CAI Jian-guang,YIN Da-zhong.Inhibiting Effects of Melatonin on Carbonyl Stress[J].Journal of Natural Science of Hunan Normal University,2007,30(3):99-104,109. |
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| Authors: | LI Guo-lin HE Hong PENG Mi-jun CAI Jian-guang YIN Da-zhong |
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| Institution: | Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences Hunan Normal University, Changsha 410081, China |
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| Abstract: | Malondialdehyde(MDA) is one of the most important intermediates of free radical damage and non-enzyme glycation in vivo.A purpose of this study is to determine whether melatonin(MT) can scavenge MDA and the effect of MT on MDA-induced carbonyl stress in blood system.Results show that MT could interact with MDA directly and inhibit MDA-induced blood viscosity increasing.The findings suggest that MT may detoxify unsaturated carbonyls and protect against tissue damage induced by oxidative stress. |
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| Keywords: | melatonin(MT) carbonyl stress malondialdehyde(MDA) blood viscosity |
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