Effect of histones from brain on DNA-synthesis in vitro |
| |
| Authors: | G Jahn I Szijan J A Burdman |
| |
| Institution: | (1) Departamento de Química Biológica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956, Buenos Aires, (Argentina) |
| |
| Abstract: | Summary The results of these experiments demonstrate that histones from brain inhibit the replication of DNA in vitro. A similar effect is observed with polylysine or polyarginine. The reversion of inhibition by polyglutamic acid or acidic proteins is completed in all cases except when the DNA is previously complexed with histones, polyarginine or polylysine. This suggest that histones masking of DNA towards the polymerases involves electrostatic forces.These studies were supported by the Consejo Nacional de Investigaciones Científicas y Técnicas and the Instituto Nacional de Farmacología y Bromatología, Argentina.Abbreviations. DNA-polymerase: deoxynucleoside triphosphate: DNA deoxynucleotidyl transferase (E.C. 2.7.7.7.). |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
