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Elevation of intracellular calcium reduces voltage-dependent potassium conductance in human T cells
Authors:P Bregestovski  A Redkozubov  A Alexeev
Abstract:Both voltage-activated potassium channels and the concentration of free intracellular calcium have been implicated in the activation of T lymphocytes. Using the patch-clamp technique, we now show an unexpected relationship between the level of intracellular calcium Ca]i in human lymphocytes and the amplitude of a voltage-dependent current: the elevation of Ca]i decreases the potassium conductance. This is in contrast to other systems where Ca]i activates K+ channels. Our results suggest that the level of intracellular calcium regulates the effective number of K+ channels capable of being activated.
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