Protection of rat gastric mucosa against ethanol injury by the new synthetic prostaglandin MDL 646 |
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| Authors: | G Pallavicini A Bardoni A Profumo A A Castellani P Schiatti A Glässer |
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| Institution: | (1) Biochemistry Department, University of Pavia, 27100 Pavia, (Italy);(2) Pharmacology Dept., Lepetit Research Labs., Via Durando, 38, 20158 Milan, (Italy) |
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| Abstract: | Summary Oral administration to fasted rats of absolute ethanol produces extensive necrotic lesions of gastric mucosa as well as a massive leakage of proteins and mucus glycoproteins into gastric lumen. When the new synthetic prostaglandin MDL 646, belonging to the PGE1 series, is administered intragastrically (2 or 10  g/kg) 30 min before ethanol administration, a significant protection of rat gastric mucosa against alcohol injury is observed.This work was supported in part by a contribution from Ministero della Pubblica Istruzione (MPI), Rome, Italy. |
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