Role of neurotransmitter release and cyclic AMP-dependent membrane phosphorylation in low voltage myocardial automaticity |
| |
| Authors: | M. E. Saxon V. G. Safronova A. V. Lazarev A. A. Freidin Y. M. Kokoz |
| |
| Affiliation: | (1) Institute of Biological Physics, USSR Academy of Sciences, 142292 Pushchino, Moscow Region;(2) Research Institute for Testing of the Chemical Compounds, Kupavna, Moscow Region, USSR |
| |
| Abstract: | Summary Low voltage myocardial automaticity (LVA) was investigated by pharmacological modulations of the presynaptic and postsynaptic processes. The sensitivity of LVA both to inhibitor and stimulator of neutrotransmitter release suggests its involvement in LVA genesis. Moreover, LVA is blocked by the inhibition of the cyclic AMP system, supporting the participation of the c-AMP-dependent membrane phosphorylation in calcium-mediated cardiac electrogenesis.Acknowledgment. The generous gift of RM1 12330A from Prof. G. Guellen, Paris, and of tolbutamide from Prof. T. Hayakawa, Tokyo, are gratefully acknowledged. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
