Allergic reactions, cyclic AMP and histamine release. |
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Authors: | P S Skov A Geisler R Klysner S Norn |
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Abstract: | Both isobutylmethylxanthine and theophylline increased the level cyclic AMP in the mast cell. Theophylline reduced the allergic histamine release, whereas isobutylmethylxynthine caused a pronounced potentiation of the histamine release. This indicates that the hypothesis of an inverse relationship between the level of cyclic AMP in mast cells and histamine release is too simple. |
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