T-cell leukemia induced by 1-propyl-1-nitrosourea in Fischer rats |
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| Authors: | N Imamura O Saito H Dohy T Ogiu |
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| Institution: | (1) Department of Internal Medicine, Research Institute for Nuclear Medicine and Biology, Hiroshima University, Kasumi 1-2-3, Hiroshing, (Japan);(2) Division of Pathology, Biological Safety Research Center, National Institute of Hygienic Sciences, Tokyo, (Japan) |
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| Abstract: | Summary T-cell leukemia was induced at a high rate in female Fischer rats by continuous oral administration of 1-propyl-1-nitrosourea. No association of oncorna viruses were found in the leukemogenesis.The authors are greatly indebted to Professor K. Yokoro of the Department of Pathology, Research Institute for Nuclear Medicine & Biology, for his valuable suggestions. This work was supported in part by a Grant-in-Aid for Cancer Research from the Ministry of Education, Science and Culture, Japan. |
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