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Ubiquitin-like and ubiquitin-associated domain proteins: significance in proteasomal degradation
Authors:Vivian Su  Alan F. Lau
Affiliation:(1) Natural Products and Cancer Biology Program, Cancer Research Center, University of Hawaii at Manoa, 651 Ilalo Street, BSB 222, Honolulu, HI 96813, USA;(2) Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii at Manoa, 651 Ilalo Street, BSB 222L, Honolulu, HI 96813, USA
Abstract:The ubiquitin–proteasome pathway of protein degradation is one of the major mechanisms that are involved in the maintenance of the proper levels of cellular proteins. The regulation of proteasomal degradation thus ensures proper cell functions. The family of proteins containing ubiquitin-like (UbL) and ubiquitin-associated (UBA) domains has been implicated in proteasomal degradation. UbL–UBA domain containing proteins associate with substrates destined for degradation as well as with subunits of the proteasome, thus regulating the proper turnover of proteins.
Keywords:UbL  UBA  Proteasome  Degradation  Ubiquitin
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