Influence of presensitization with allogeneic lymphoma cells on the growth and response to therapy of radiation-induced lymphomas in mice

Summary Congenic mice were sensitized with viableH-2-incompatible radiation-induced lymphomas (RIL), challenged with syngeneic RIL and treated with bis-chloroethyl-nitrosourea. Either enhancement or inhibition of RIL was found in presensitized mice, depending on the tumor-host system used.This work was supported by Progetto Finalizzato Virus, CNR (Rome, Italy), Contract No. 770025284/1152505.Acknowledgments. I wish to thank Dr J. Mayo and Mr C.R. Reeder of the Mammalian Genetics and Animal Production Section, Division of Cancer Treatment (DCT), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda (Maryland, 20014, USA) for providing the mice used in this study. I also thank Dr H.B. Wood of the Drug Synthesis and Chemistry Branch, DCT, NCI, NIH, for furnishing the BCNU used.