The elegans of spindle assembly |
| |
Authors: | Thomas Müller-Reichert Garrett Greenan Eileen O’Toole Martin Srayko |
| |
Institution: | 1. Medical Theoretical Center (MTZ), TU Dresden, Fetscherstra?e 74, 01307, Dresden, Germany 2. Max Planck Institute of Molecular Cell Biology and Genetics (MPICBG), Pfotenhauerstr. 108, 01307, Dresden, Germany 3. Boulder Laboratory for 3D Electron Microscopy of Cells, University of Colorado, Boulder, CO, 80309, USA 4. Department of Biological Sciences, University of Alberta, Edmonton, AB, T6G 2E9, Canada
|
| |
Abstract: | The Caenorhabditis elegans one-cell embryo is a powerful system in which to study microtubule organization because this large cell assembles both meiotic
and mitotic spindles within the same cytoplasm over the course of 1 h in a stereotypical manner. The fertilized oocyte assembles
two consecutive acentrosomal meiotic spindles that function to reduce the replicated maternal diploid set of chromosomes to
a single-copy haploid set. The resulting maternal DNA then unites with the paternal DNA to form a zygotic diploid complement,
around which a centrosome-based mitotic spindle forms. The early C. elegans embryo is amenable to live-cell imaging and electron tomography, permitting a detailed structural comparison of the meiotic
and mitotic modes of spindle assembly. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|